341 In addition, many neutrophils can migrate to the lungs via the bloodstream in response to chemokine signaling, where the release of NETs and matrix metalloproteinases can disrupt alveolar capillaries, contributing to ALI, a hallmark of AP-ALI
1 The study details 800 participants in the interim analysis (1,197 total enrolled) with biopsy-confirmed MASH and moderate to severe fibrosis (stage F2 or F3) Participants were randomly assigned to receive semaglutide 2.4 mg weekly or placebo Treatment lasted 72 weeks 2:1 randomisation (534 semaglutide, 266 placebo) Resolution of MASH (primary outcome) Fibrosis improvement (primary outcome) Combined outcomes About a third (32.7%) of participants taking semaglutide achieved both MASH resolution and fibrosis improvement, compared to 16.1% on placebo
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For some people, GI effects like diarrhea and nausea can be severe and make it difficult to continue with Ozempic
